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Diseases/Injuries of Serum therapy
News
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2022.03.07
- For All
Website renewed.
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2021.10.05
- Blog
Lonaprevive and sotrobimab – From SARs-CoV-2 specific neutralizing antibody to broad neutralizing antibody – from Dr. Joe Chiba
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2021.10.01
- Blog
Changes in the treatment of venomous snake bites in Japan (from Dr. Atsushi Sakai)
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2021.07.28
- For medical professionals
Equine serum hypersensitivity test when using pit viper antivenom was summarized in collaboration with Meiji Seika Pharma, Inc./KM Biologics, Inc.
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2021.07.19
- Blog
Production of domestic redback spider antitoxin and preclinical studies
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2021.01.31
- Blog
Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU First Update
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2021.01.01
- Blog
Prof. Motohide Takahashi introduced the history of serum therapy.
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2020.10.02
- For medical professionals
Co-researcher Professor Emeritus Joe Chiba of the Tokyo University of Science explains serum therapy for novel coronavirus infections in Nikkei Biotech (Part 3).
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2020.09.26
- For medical professionals
Co-researcher Professor Emeritus Joe Chiba of the Tokyo University of Science explains serum therapy for novel coronavirus infections in Nikkei Biotech (Part 2).
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2020.09.05
- For medical professionals
Co-researcher Joe Chiba, Professor Emeritus of Tokyo University of Science, explains serum therapy for novel coronavirus infections in Nikkei Biotech.
Serum therapy
Currently, the only facility in Japan capable of producing antitoxin and antiserum is KMB (formerly the Research Institute for Chemotherapy and Serotherapy, Kumamoto).
In the case of equine serum, equine immunoglobulin is purified from the serum or plasma obtained by immunizing equines and collecting their blood, which is then filled into vials and formulated.
Production process of
bovine antitoxin preparation (example)
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Bovine immunization process
- Immunization (basic, additional)
- Blood collection
- Serum and plasma separation
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Antivenom purification process
- Pepsin digestion
- Salting out, dialysis
- Stock solution preparation
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Manufacturing process
- Final bulk preparation
- Filling
- Lyophilization, sealing
